Gene targeting
Mario Capecchi
He developed principles of gene targeting in mice.
The problem
A question worth answering.
Studying gene function in mammals required precise changes.
What they did
He developed principles of gene targeting in mice.
What changed
Targeted models became a core research method.
Where you meet their legacy
In the knowledge, systems and people who carry the work forward today.
Evidence and further reading
This story does not assign sole credit for a collective achievement.